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Hydrogen Peroxide → 4-Piperidinol, 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethyl-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | 1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine | HCID 5395 | — |
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 生成物 | 4-Piperidinol, 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethyl- | HCID 6850828 | — |
反応手順
A solution of 50% aqueous hydrogen peroxide is added to a mixture of 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine and ferrous chloride tetrahydrate in tert-butyl alcohol at 30-60° C. Excess peroxide is decomposed with aqueous sodium sulfite. The organic layer is concentrated and the crude product is purified by flash chromatography on silica gel to afford a sample of 4-hydroxy-1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271377B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-05aae43d3a8a489b8ec0b770e09a4d6b |
| 出典メモ | uspto-grants-2001_08 |