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Tetrahydrofuran → 4-n-Butylidene-4,5,6,7-tetrahydrobenzo[b]furan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 4,5,6,7-Tetrahydro-1-benzofuran-4-one | HCID 2733541 | — |
| 反応物 | HCID 178418682 | HCID 178418682 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-n-Butylidene-4,5,6,7-tetrahydrobenzo[b]furan | HCID 54518756 | — |
反応手順
To a mixture of 4-oxo-4,5,6,7-tetrahydrobenzo[b]furan (20.06 g) and THF (200 ml) was added dropwise 2M n-butylmagnesium bromide with ice-water cooling over 15 minutes. The mixture was stirred at r.t. overnight. The reaction mixture was poured into a mixture of a saturated aqueous solution of NH4Cl and AcOEt. The separated organic layer was washed with water and brine, and dried over MgSO4, and evaporated. The resulting oil was purified by chromatography on SiO2 (CHCl3 as eluent) to give 4-n-butylidene-4,5,6,7-tetrahydrobenzo[b]furan as a yellow oil (12.06 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06274619B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-274df34808e2475186d75710ee35a1fe |
| 出典メモ | uspto-grants-2001_08 |