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Benzene → 2-Chloro-4-fluoro-1-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene | HCID 241 | — |
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 1-Chloro-3-fluorobenzene | HCID 223087 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-Chloro-4-fluoro-1-nitrobenzene | HCID 75017 | 16.7% |
反応手順
m-Chlorofluorobenzene (240 g. 1.85 moles) is added to a mixture of sulfuric acid (185 g. 1.85 moles) and nitric acid (166 g., 1.85 moles) at -5° C. in 3.5 hours, stirred 13 hours, then benzene (200 ml.) and hexane (200 ml.) are added. The extract is washed with water (1×300 ml.), sodium carbonate solution (1×300 ml.), and water (1×300 ml.), dried and the solvents removed. The residue is distilled to give 138 g. of mixture isomers. The 4-nitro isomer crystallizes and is filtered off to give 3-chloro-4-nitrofluorobenzene (51 g. 16.7%) m.p. 36°-38° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04613360 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-355d292c1c8444b6a63c811435ffb1f9 |
| 出典メモ | uspto-grants-1986_09 |