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Hydrochloric Acid → 6-Chloro-2-(2,4-dichlorobenzoyl)-pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,3-Dichlorobenzene | HCID 10943 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 6-chloropyridine-2-carbonyl Chloride | HCID 10942976 | — |
| 生成物 | 6-Chloro-2-(2,4-dichlorobenzoyl)-pyridine | HCID 20145714 | — |
反応手順
40.9 g AlCl3 is added in portions to a mixture of 26.4 g 6-chloro-2-pyridinecarboxylic acid chloride and 112 g 1,3-dichlorobenzene. The mixture is slowly heated until 130°-40° C. After standing overnight, it is added to a mixture of diluted HCl and crushed ice, basified and extracted with ethyl ether. The ethereal extracts are washed with water, dried and solvent evaporated (water pump). The residual deep green oil is crystallised from ethanol: water in the presence of decolorizing carbon. Yield: 10 g title compound, m.p. 103°-4° C.; UV (ethanol): λmax. 281 nm; ε: 14,500; Cl 37.02 (37.12).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04614833 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-1e606b91cf6d41398a9a4167ddca2ab4 |
| 出典メモ | uspto-grants-1986_09 |