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4-Ethylphenyl isocyanate → 2-(3-(2,3-Dichlorobenzyl)-1-methylureido)ethyl 4-ethylphenylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Ethylphenyl isocyanate | HCID 90007 | — |
| 反応物 | 3-(2,3-Dichlorobenzyl)-1-(2-hydroxyethyl)-1-methylurea | HCID 59778452 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(3-(2,3-Dichlorobenzyl)-1-methylureido)ethyl 4-ethylphenylcarbamate | HCID 59778439 | 6.5% |
反応手順
To a solution of 3-(2,3-dichlorobenzyl)-1-(2-hydroxyethyl)-1-methylurea (70 mg, 0.27 mmol) in DMF were added DMAP and 4-ethylphenylisocyanate (80 mg, 0.54 mmol). The reaction mixture was stirred overnight. The reaction mixture was concentrated. The resulting residue was purified on RP-HPLC using a mixture of acetonitrile and H2O to give 2-(3-(2,3-dichlorobenzyl)-1-methylureido)ethyl 4-ethylphenylcarbamate (7 mg, 6.5%). LRMS (M+H+) m/z 424.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08071625B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-32b7617d257445808400cbcd93ff2792 |
| 出典メモ | uspto-grants-2011_12 |