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2-Propynenitrile → 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propynenitrile | HCID 14055 | — |
| 反応物 | (3Z)-3-diazo-1H-indol-2-one | HCID 136455454 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 5,6-Dihydro-5-oxopyrazolo[1,5-c]quinazoline-2-carbonitrile | HCID 135735621 | — |
反応手順
6.0 g (0.04 mole) of 3-diazooxindole and 2.2 g (0.045 mole) of cyanoacetylene are taken up in benzene (250 ml) and refluxed overnight under N2. The mixture is cooled and the beige-colored precipitates are filtered off. The crude product is dried in a vacuum oven at room temperature for 3 hours. Yield: 5.2 g, m.p. 302°-304°. Percent yield: 65.6.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04128644 |
| 出典データセット | uspto-grants-1978_12 |
| ORD ID | ord-17badc783a4f4776bd16b92132f8856e |
| 出典メモ | uspto-grants-1978_12 |