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4-Fluorobenzyl bromide → 4-((N-(4-fluorobenzyl)-1-phenylmethylsulfonamido)methyl)-cyclohexanecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorobenzyl bromide | HCID 68021 | — |
| 反応物 | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| 反応物 | (1R,4R)-Methyl 4-(aminomethyl)cyclohexanecarboxylate | HCID 12721444 | — |
| 生成物 | 4-((N-(4-fluorobenzyl)-1-phenylmethylsulfonamido)methyl)-cyclohexanecarboxylic acid | HCID 57450324 | — |
反応手順
Prepared as in example 5-10 from phenylmethanesulfonyl chloride and methyl 4-(aminomethyl)cyclohexanecarboxylate and 1-(bromomethyl)-4-fluorobenzene. MS (M−H, 418); 1NMR (400 MHz, DMSO-d6): δ, ppm: 0.639 (m, 2H), 0.897 (m, 2H), 1.034 (m, 1H), 1.467 (d, broad, 2H, J=11.2 Hz), 1.709 (d, broad, 2H, J=11.2 Hz), 1.961 (m, 1H), 2.828 (d, 2H, J=7.6 Hz), 4.207 (s, 2H), 4.449 (s, 2H), 7.155 (t, 2H, J=9.2 Hz), 7.377 (m, 7H), 12 (s, broad, 1H)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08076491B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-55feabda43304eb9993862141bfce6b8 |
| 出典メモ | uspto-grants-2011_12 |