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4-((2-Fluorophenyl)methoxy)benzaldehyde → Priralfinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-((2-Fluorophenyl)methoxy)benzaldehyde | HCID 702717 | — |
| 反応物 | (S)-2-aminopropanamide hydrochloride | HCID 2775816 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | Priralfinamide | HCID 5745207 | 70% |
反応手順
A mixture of 5 g of 4-(2-fluorobenzyloxy)benzaldehyde, prepared according to the Ex. 1 and the corresponding amount L-alaninamide hydrochloride and triethylamine is hydrogenated according to the same procedure of Example 2, but using wet (50% H2O) Pd/C 10% instead of wet (50% H2O) Pt/C 5% to obtain (S)-2-[4-(2-fluorobenzyloxy)benzylamino]propanamide (Ib) in a 70% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08076515B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-984dea845a87462baa6e61b3b4373320 |
| 出典メモ | uspto-grants-2011_12 |