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Methanol → Methyl 2-(3-amino-4-hydroxyphenyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Methyl 2-(4-hydroxy-3-nitrophenyl)acetate | HCID 1473109 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 2-(3-amino-4-hydroxyphenyl)acetate | HCID 1475136 | — |
反応手順
Methyl-2-(4-hydroxy-3-nitrophenyl)acetate (2.31 g, 10.9 mmol) was dissolved in THF (20 mL) and MeOH (20 mL) and 10% palladium on carbon (210 mg) was added slowly at RT. The reaction mixture was hydrogenated for 2 h at 39 psi hydrogen pressure, filtered through Celite and washed with MeOH. The solvent was removed under a vacuum and the residue purified by means of column chromatography (n-hexane/EA=2:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08084484B2 |
| 出典データセット | uspto-grants-2011_12 |
| ORD ID | ord-bac8935b6b8e4d89b1b163b2790afde2 |
| 出典メモ | uspto-grants-2011_12 |