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Methanol → 2-Amino-3-n-propoxy-5-methylpyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2,3-Dichloropyrazine | HCID 78575 | — |
| 反応物 | 2-Amino-3-bromo-5-methylpyrazine | HCID 9899043 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | 2-Amino-3-n-propoxy-5-methylpyrazine | HCID 20528988 | — |
反応手順
By replacing the 2,3-dichloropyrazine and anhydrous methanol used in Preparation 43 by equivalent quantities of the product of Step A and n-propanol and following the method described in Preparation 43, 2-amino-3-n-propoxy-5-methylpyrazine is obtained. The 2-amino group can be converted to the 2-hydroxy by the method described by Sharp et al, ibid., (see Route III) which when treated with phosphorus oxychloride by the method of Preparation 13, Step B, provides 2-chloro-3-n-propoxy-5-methylpyrazine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04343802 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-b93782a1711d49f8a1b8b8f708f73639 |
| 出典メモ | uspto-grants-1982_08 |