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Hydrochloric Acid → Cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Dichloromethyl-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one | HCID 20492984 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid | HCID 41507 | — |
反応手順
Potassium tertiary butoxide (0.45 mol) was added to a solution of 4-dichloromethyl-6,6-dimethyl-3-oxabicyclo[3.1.0]-hexan-2-one (0.16 mmol) in dry dimethylsulphoxide (0.4 ml) and stirred at room temperature for 1/2 hour. The solution was then diluted with water, acidified with concentrated hydrochloric acid and extracted CDCl3. NMR analysis showed a virtually quantitative yield of the desired cis acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04346038 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-78c9fa680c9548668ca5189c8a5276c2 |
| 出典メモ | uspto-grants-1982_08 |