関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | Sarcosine | HCID 1088 | — |
| 反応物 | 6-Fluoroisatoic anhydride | HCID 2783057 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-Fluoro-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione | HCID 22914547 | — |
反応手順
7.2 g (0.04 mol) of 6-fluoroisatoic acid anhydride and 3.9 g (0.044 mol) of sarcosine are added to 10 ml of dimethyl sulphoxide and the mixture is heated at 100° C. for 30 minutes. After cooling and diluting with 15 ml of water, the separated substance is filtered off. After drying, there is obtained 6-fluoro-3,4-dihydro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione of melting point 214°-217° C. (decomposition).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04346032 |
|---|
| 出典データセット | uspto-grants-1982_08 |
|---|
| ORD ID | ord-ed109a50c6c74785aa0911eec8671bdd |
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| 出典メモ | uspto-grants-1982_08 |
|---|
