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(+-)-p-Methoxyamphetamine → 1-(p-Methoxyphenyl)-2-propanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+-)-p-Methoxyamphetamine | HCID 31721 | — |
| 反応物 | 3-Methyl-1,2,3,4-tetrahydroisoquinolin-7-ol | HCID 22018519 | — |
| 生成物 | 1-(p-Methoxyphenyl)-2-propanone | HCID 31231 | — |
| 生成物 | 7-Methoxy-1,2,3,4-Tetrahydroisoquinoline | HCID 417288 | — |
| 生成物 | 1,2,3,4-Tetrahydroisoquinolin-7-ol | HCID 419268 | — |
反応手順
7-Methoxy-1,2,3,4-tetrahydro-isoquinoline and 1,2,3,4-tetrahydro-isoquinolin-7-ol were prepared by a literature procedure (J. Med. Chem. 1987, 30, 2208–2216). 2-(4-Methoxy-phenyl)-1-methyl-ethylamine required for the preparation of 3-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol was obtained from 1-(4-methoxy-phenyl)-propan-2-one by Procedure X and was subsequently converted to the tetrahydroisoquinoline by the same literature method.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084154B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f405ed59b2104cc7a767f0e2836109f2 |
| 出典メモ | uspto-grants-2006_08 |