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2-Iodotoluene → 1-(3-o-Tolyl-2-propynyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Iodotoluene | HCID 5128 | — |
| 反応物 | 1-(Prop-2-yn-1-yl)piperidine | HCID 336652 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418903 | HCID 178418903 | — |
| 溶媒 | Diethylamine | HCID 8021 | — |
| 生成物 | 1-(3-o-Tolyl-2-propynyl)piperidine | HCID 12056783 | 62.3% |
反応手順
A mixture of 2-iodotoluene (6.54 g), N-(2-propynyl)piperidine (3.69 g), dichlorobis(triphenylphosphino)palladium(II) (0.05 g) and copper(I) iodide (0.1 g) in dry diethylamine (50 ml) was heated under reflux for 5 hours. The solvent was removed under reduced pressure and the residue was taken up in diethyl ether and washed with water. The organic phase was dried over magnesium sulfate and concentrated completely under reduced pressure. Distillation of the residue under reduced pressure gave 3.98 g of an oil of boiling point 96–98° C./0.08 mm Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07084158B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-0f8d0671097c4c1fb7b5e5e1778ceb8b |
| 出典メモ | uspto-grants-2006_08 |