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Methoxyacetic Acid → 2-Chloroethyl 2-(methoxyacetyl)-2-(2,6-dimethylphenyl)-hydrazinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methoxyacetic Acid | HCID 12251 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Methoxyacetyl chloride | HCID 96623 | — |
| 反応物 | 2-Chloroethyl 2-(2,6-dimethylphenyl)-hydrazinecarboxylate | HCID 13036493 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 2-Chloroethyl 2-(methoxyacetyl)-2-(2,6-dimethylphenyl)-hydrazinecarboxylate | HCID 20454494 | — |
反応手順
200 g (0.825 mol) 2-Chloroethyl 2-(2,6-dimethylphenyl)-hydrazinecarboxylate in 500 ml xylene are warmed to 80°, and added to a warm (80°) solution of 2-methoxyacetylchloride in 250 ml xylene, prepared in situ by treating 73.5 g (0.826 mol) 2-methoxyacetic acid in 250 ml xylene with 107.1 g (0.9 mol) thionyl chloride at 80° for 2 hours. The mixture is heated for 30 minutes at 80°, then worked up as described in Example 1a.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04347253 |
| 出典データセット | uspto-grants-1982_08 |
| ORD ID | ord-6096314213fa4998bf197d11be76b84e |
| 出典メモ | uspto-grants-1982_08 |