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Imidazo[1,2-a]pyridine-6-carbaldehyde → 5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazo[1,2-a]pyridine-6-carbaldehyde | HCID 7164582 | — |
| 反応物 | 5-Fluoroquinoline-6-carbaldehyde | HCID 57917315 | — |
| 反応物 | 3-Bromo-6-(1-methyl-1h-pyrazol-4-yl)-imidazo[1,2-b]pyridazine | HCID 68632486 | — |
| 生成物 | 5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline | HCID 57917488 | — |
反応手順
(rac)-(5-Fluoro-quinolin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol was obtained analogously to Stage 9.1 by replacing 3-bromo-6-chloro-imidazo[1,2-b]pyridazine with 3-bromo-6-(1-methyl-1h-pyrazol-4-yl)-imidazo[1,2-b]pyridazine (Stage 8.1) and imidazo[1,2-a]pyridine-6-carbaldehyde with 5-fluoro-quinoline-6-carbaldehyde (Intermediate A) (tR 0.90 min (conditions 1), (MH+=375).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822468B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-439889cdcf884be28c6710a5346c474e |
| 出典メモ | uspto-grants-2014_09 |