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Di-tert-butyl dicarbonate → tert-Butyl (6-chloro-2-methylpyrimidin-4-yl)carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Di-tert-butyl dicarbonate | HCID 90495 | — |
| 反応物 | 6-Chloro-2-methylpyrimidin-4-amine | HCID 286754 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | tert-Butyl (6-chloro-2-methylpyrimidin-4-yl)carbamate | HCID 86669200 | 78% |
反応手順
To a solution of 6-chloro-2-methylpyrimidin-4-amine (1.0 equiv.) in THF (0.17M) was added BOC2O (1.1 equiv.) and DMAP (cat.). The reaction was allowed to stir overnight, then concentrated to a yellow crude, and filtered through a pad of SiO2 eluting with EtOAc and hexanes (1:1) to afford an off-white solid (78%). LCMS (m/z): 244.1 (MH+); LC Rt=3.69 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822497B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b14ebb2ce44f4a2aa62d0ea25d21e640 |
| 出典メモ | uspto-grants-2014_09 |