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Dichloromethane → 2-(1-Phenyl-cyclohexyl)-thiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Thiophene | HCID 8030 | — |
| 反応物 | 1-Phenylcyclohexene | HCID 13043 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Hydrogen Bromide | HCID 260 | — |
| 生成物 | 2-(1-Phenyl-cyclohexyl)-thiophene | HCID 66968119 | — |
反応手順
Phenyl cyclohexene (50 mg) and thiophene (100 mg) were dissolved in 33% HBr in acetic acid (0.5 mL). The mixture was stirred at room temperature over night. Tlc indicated full conversion of the starting material. Dichloromethane (10 mL) was added. The organic phase was washed with saturated NaHCO3 (3×10 mL), dried Na2SO4 and concentrated in vacuo. The desired product was afforded after flash chromatography (eluent: dichloromethane). Yield: 39 mg. LC/MS purity (UV/MS): 100/90%, Rt 6.22 min. M+1: 243
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822548B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7c2b84a7b779425e99164e43cf496820 |
| 出典メモ | uspto-grants-2014_09 |