関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1H-Benzimidazole-2-acetonitrile | HCID 20455 | — |
| 反応物 | Ammonium Acetate | HCID 517165 | — |
| 反応物 | Methyl 4-oxothiane-3-carboxylate | HCID 10374916 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 12-oxo-3,4,6,12-tetrahydro-1H-thiopyrano[4',3':4,5]pyrido[1,2-a]benzimidazole-5-carbonitrile | HCID 71268644 | 68.8% |
反応手順
A mixture of 1H-benzimidazol-2-ylacetonitrile (13 g), methyl 4-oxotetrahydro-2H-thiopyran-3-carboxylate (15.3 g), and ammonium acetate (33 g) was heated and stirred at 140° C. for 1 hour. The reaction mixture was cooled to room temperature, water and acetonitrile were added, and the resulting precipitate was collected by filtration and dried under reduced pressure to obtain 12-oxo-3,4,6,12-tetrahydro-1H-thiopyrano[4′,3′:4,5]pyrido[1,2-a]benzimidazole-5-carbonitrile (16 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08822688B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-1911c51393d64009890652cfd444e22a |
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| 出典メモ | uspto-grants-2014_09 |
|---|
