化工社化工社 化学情報印刷レポート · 研究参考用
Water → [4-(3,4-Dichloro-benzyloxy)-phenyl]-oxo-acetaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Hydroxyphenylglyoxal | HCID 90568 | — |
| 反応物 | 4-(Bromomethyl)-1,2-dichlorobenzene | HCID 639726 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [4-(3,4-Dichloro-benzyloxy)-phenyl]-oxo-acetaldehyde | HCID 86654900 | 84.1% |
反応手順
To a solution of (4-hydroxy-phenyl)-oxo-acetaldehyde (756 mg) in dry DMF (10 mL) was added 3,4-dichlorobenzylbromide (1.2 g) and potassium carbonate (1.03 g). After 4 hours, the reaction mixture was poured into water (100 mL) and extracted with ethyl acetate (2×50 mL). The organic extracts were combined and washed with brine (2×50 mL) and saturated sodium bicarbonate solution (2×50 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give [4-(3,4-dichloro-benzyloxy)-phenyl]-oxo-acetaldehyde (1.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09175003B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-53964a4bb2294f3b85897efa05e7f131 |
| 出典メモ | uspto-grants-2015_11 |