化工社化工社 化学情報印刷レポート · 研究参考用
p-Diiodobenzene → 2,2,2-Trifluoro-1-(1-(3-(4-iodophenyl)prop-2-ynyl)-1H-indol-3-yl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Diiodobenzene | HCID 12208 | — |
| 反応物 | 1-Octyne | HCID 12370 | — |
| 反応物 | 5-Iodo-2-tritylisoindoline | HCID 66726248 | — |
| 反応物 | 2,2,2-Trifluoro-1-(1-(prop-2-ynyl)-1H-indol-3-yl)ethanone | HCID 86661769 | — |
| 生成物 | 2,2,2-Trifluoro-1-(1-(3-(4-iodophenyl)prop-2-ynyl)-1H-indol-3-yl)ethanone | HCID 66726498 | 51% |
反応手順
When the product of Step B was substituted for 1-octyne and 1,4 diiodobenzene was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 51% yield, as light yellow solid. 1H-NMR (CDCl3) 5.16 (s, 2H); 7.14 (d, 2H, J=8.30 Hz); 7.38-7.44 (m, 2H); 7.51-7.55 (m, 1H); 7.66 (tr, 2H, J=8.36 Hz); 8.12 (b, 1H); 8.40-8.43 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181182B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-b80106d425bd4072ba7d37a6c0cb9ef0 |
| 出典メモ | uspto-grants-2015_11 |