化工社化工社 化学情報印刷レポート · 研究参考用
1-Octyne → tert-Butyl-5-((4-((4-(4-fluorobenzoyl)phenyl)ethynyl)phenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Octyne | HCID 12370 | — |
| 反応物 | (4-Ethynylphenyl)(4-fluorophenyl)methanone | HCID 23352815 | — |
| 反応物 | 5-Iodo-2-tritylisoindoline | HCID 66726248 | — |
| 反応物 | tert-Butyl 5-((4-iodophenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate | HCID 66726604 | — |
| 生成物 | tert-Butyl-5-((4-((4-(4-fluorobenzoyl)phenyl)ethynyl)phenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate | HCID 131733936 | 42% |
反応手順
When the product of Step D was substituted for 1-octyne and tert-butyl-5-((4-iodophenyl)ethynyl)-2,2-dimethyl-1,3-dioxan-5-ylcarbamate was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 42% yield, as creamy paste. 1H-NMR (CDCl3) 1.44 (s, 3H); 1.47 (s, 9H); 1.5 (s, 3H); 4.02 (d, 2H, J=11.37 Hz); 4.1 (d, 2H, J=11.31 Hz); 5.2 (s, 1H); 7.16 (tr, 2H, J=8.64 Hz); 7.40 (d, 2H, J=8.49 Hz); 7.46 (tr, 2H, J=8.46 Hz); 7.60 (d, 2H, J=8.43 Hz); 7.74 (d, 2H, J=8.39 Hz); 7.80-7.83 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09181182B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-2530f3f108a047e49b16a2c038899ce1 |
| 出典メモ | uspto-grants-2015_11 |