化工社化工社 化学情報印刷レポート · 研究参考用
2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 反応物 | 6-Aminoindole | HCID 256096 | — |
| 生成物 | 2-chloro-5-fluoro-N4-[(1H)indol-6-yl]-4-pyrimidineamine | HCID 22060459 | — |
反応手順
In a like manner to the preparation of 2-chloro-N4-(3,4-ethylenedioxyphenyl)-5-fluoro-4-pyrimidineamine, 2,4-dichloro-5-fluoropyrimidine and 6-aminoindole were reacted to provide 2-chloro-5-fluoro-N4-[(1H)-indol-6-yl]-4-pyrimidineamine. LCMS: purity: 92%; MS (m/e): 263 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08822685B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-9e9c43c0721747f8a1ba4d836c00ceb2 |
| 出典メモ | uspto-grants-2014_09 |