化工社化工社 化学情報印刷レポート · 研究参考用
Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 反応物 | ST51005980 | HCID 2725051 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N,N'-Dicyclohexylurea | HCID 4277 | — |
反応手順
To a stirred solution of 5- or 6-carboxyfluorescein (0.5 mmol) in dry DMF (5 mL) were added N-hydroxysuccinimide (1.1 equiv.) and 1,3-dicylcohexylcarbodiimide (1.1 equiv.). After about 10 minutes, a white solid (dicyclohexylurea) started forming. The reaction mixture was stirred under nitrogen at room temperature overnight. TLC (thin layer chromatography; 9:1 CH2Cl2—MeOH) indicated complete disappearance of the starting material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07135300B2 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-b54c84f8f5f24bd189c9d319bc479b86 |
| 出典メモ | uspto-grants-2006_11 |