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Phenacyl bromide → 1-Benzoyl-6-chloro-3-cyano-pyrrolo[1,2-a]quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenacyl bromide | HCID 6259 | — |
| 反応物 | 6-Chloroquinoline | HCID 69163 | — |
| 反応物 | 5-Chloro-1-phenacyl-quinolinium bromide | HCID 21892114 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1-Benzoyl-6-chloro-3-cyano-pyrrolo[1,2-a]quinoline | HCID 10404418 | — |
反応手順
5-Chloro-1-phenacyl-quinolinium bromide: The title compound was prepared from 2-bromo-1-phenyl-ethanone (490 mg, 2.46 mmol), 6-chloro-quinoline (314 mg, 1.92 mmol) and acetonitrile (5 mL), similar to Example 1a, and yielded 394 mg (57%) as a light tan solid: 1H NMR (CDCl3) 10.55 (dd, J=1.2, 6.0 Hz, 1H), 9.41 (d, J=8.7 Hz, 1H), 8.32 (m, 1H), 8.30 (m, 1H), 8.23 (dd, J=6.0, 9.0 Hz, 1H), 8.05–7.99 (m, 3H), 7.70 (m, 3H), 7.55 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07135480B2 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-87961bf710634f92b2a263f22ba47803 |
| 出典メモ | uspto-grants-2006_11 |