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Thiophenol → N-{4-[2-Amino-3,5-dicyano-6-(phenylsulphanyl)-4-pyridinyl]phenyl}acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiophenol | HCID 7969 | — |
| 反応物 | Malononitrile | HCID 8010 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-(4-(2,2-Dicyanoethenyl)phenyl)acetamide | HCID 33296 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-{4-[2-Amino-3,5-dicyano-6-(phenylsulphanyl)-4-pyridinyl]phenyl}acetamide | HCID 12016387 | — |
反応手順
19 g (0.09 mol) of N-[4-(2,2-dicyanovinyl)phenyl]acetamide, 5.95 g (0.09 mol) of malononitrile and 9.91 g (0.09 mol) of thiophenol are initially charged in 120 ml of ethanol, and 0.4 ml of triethylamine are added. The mixture is stirred at reflux for 2 h, during which the product crystallizes. After cooling, the product is filtered off with suction and dried under reduced pressure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07135486B1 |
| 出典データセット | uspto-grants-2006_11 |
| ORD ID | ord-9db1f65e28f44eb980bc6e416322f632 |
| 出典メモ | uspto-grants-2006_11 |