化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 2-Methyl-4-(N-ethyl-N-(beta-hydroxyethyl)amino)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 4-Nitrobenzyl chloroformate | HCID 78205 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 生成物 | 2-Methyl-4-(N-ethyl-N-(beta-hydroxyethyl)amino)aniline | HCID 75383 | — |
反応手順
To 50 mg of Rho575 in dimethylformamide, 53 μl of N,N′-diisopropylethylamine was added followed by 78 mg of p-nitrobenzyl chloroformate dissolved in dimethylformamide. The reaction mixture was stirred for 3 days and the solvent was removed in vacuo. The residue was dissolved in chloroform and purified on a Biotage SP4 System with a SNAP 25 g column and a chloroform methanol gradient, to give a pink product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828678B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b9f955955cb84d719a000429b1b8dc1f |
| 出典メモ | uspto-grants-2014_09 |