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Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)azetidin-1-yl)nicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| 反応物 | 3-[4-(Trifluoromethyl)phenoxy]azetidine | HCID 12812499 | — |
| 生成物 | Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)azetidin-1-yl)nicotinate | HCID 67958398 | 66.7% |
反応手順
The title compound (D78) (200 mg) was prepared according to the experimental procedure described in Description 62 starting from Methyl 2,5-dichloronicotinate (160 mg, 0.775 mmol) and 3-(4-(trifluoromethyl)phenoxy)azetidine (D52) (202.13 mg, 0.903 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08828987B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b6292d67aaff47f0bb1b6beedde8dae3 |
| 出典メモ | uspto-grants-2014_09 |