化工社化工社 化学情報印刷レポート · 研究参考用
Chloromethyl Methyl Ether → 4-Bromo-2-(2-methoxymethoxyethyl)-anisole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-(5-Bromo-2-methoxyphenyl)ethan-1-ol | HCID 1502017 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Bromo-2-(2-methoxymethoxyethyl)-anisole | HCID 21458595 | — |
反応手順
1.48 g of N-ethyl-diisopropylamine and 0.49 g of chlorodimethyl ether are added at room temperature to a solution of 948 mg of 4-bromo-2-(2-hydroxyethyl)-anisole in 30 ml of dichloromethane. The reaction mixture is stirred for 200 minutes at room temperature, and then 1 ml of water and 1 ml of 25% ammonium hydroxide solution are added thereto. The two-phase mixture is stirred vigorously for a further 15 minutes and then the organic phase is separated off, dried over sodium sulfate and concentrated by evaporation. Purification of the residue by means of FC (hexane/dichloromethane=1:1) yields the title compound: Rf (dichloromethane)=0.6; HPLC Rt =17.33 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05705658 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-9ba169e91a2e41ddab8d04366de1bc14 |
| 出典メモ | uspto-grants-1998_01 |