化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 2,3-Difluoro-6-methoxyphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | Trimethyl borate | HCID 8470 | — |
| 反応物 | n-Butyl lithium | HCID 61028 | — |
| 反応物 | 3,4-Difluoroanisole | HCID 568250 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2,3-Difluoro-6-methoxyphenol | HCID 3269728 | — |
反応手順
Using the procedure of Example 39, 125 g of 3,4-difluoro-anisole (commercial) and 500 ml of a 1.6M solution of N-butyllithium in hexane were reacted at -72° C., and then 92.4 ml of trimethylborate, 500 ml of hydrochloric acid and 120 g of intermediate compound were reacted and the product was reacted with 440 ml of 30% hydrogen peroxide to obtain 82.4 g of the expected product melting at 46.6° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05712266 |
| 出典データセット | uspto-grants-1998_01 |
| ORD ID | ord-9ef8f989905549b9bc286a83b715ef5b |
| 出典メモ | uspto-grants-1998_01 |