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Dideoxycytidine → Diisopropylaminomethylene 2',3'-dideoxycytidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dideoxycytidine | HCID 24066 | — |
| 反応物 | Diisopropylformamide Dimethylacetal (>90%) | HCID 13161384 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diisopropylaminomethylene 2',3'-dideoxycytidine | HCID 131717010 | 79.3% |
反応手順
In a typical reaction--previously dried 2',3'-dideoxycytidine (153 mg, 0.724 mmoles) prepared by the literature procedures described above is treated with diisopropylformamide dimethylacetal (1.27 g, 7.24 mmoles) in anhydrous DMF (2 mL) under an argon atmosphere. The contents are stirred overnight and then the solvent and excess reagent are removed by rotary evaporation. The syrupy residue remaining is crystallized from ethanol-ether to give pale lemon-colored crystals (185 mg, 79%) of diisopropylaminomethylene 2',3'-dideoxycytidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05051498 |
| 出典データセット | uspto-grants-1991_09 |
| ORD ID | ord-fa786e27cfb34f2f97e82278b77890f2 |
| 出典メモ | uspto-grants-1991_09 |