化工社化工社 化学情報印刷レポート · 研究参考用
p-(Trifluoromethoxy)benzenesulphonyl chloride → N-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-trifluoromethoxy-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-(Trifluoromethoxy)benzenesulphonyl chloride | HCID 523102 | — |
| 反応物 | (2-Amino-5-bromophenyl)(pyridin-4-yl)methanone | HCID 13549724 | — |
| 生成物 | N-[4-Bromo-2-(pyridine-4-carbonyl)-phenyl]4-trifluoromethoxy-benzenesulfonamide | HCID 10413664 | — |
反応手順
The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 138 mg of (2-Amino-5-bromo-phenyl)-pyridin-4-yl-methanone and 130 mg of 4-Trifluoromethoxy-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 7.23 (d, 2H, J=8.0 Hz), 7.45 (m, 3H), 7.71 (m, 2H), 7.85 (d, 2H, J=8.8 Hz), 8.85 (d, 2H, J=6.4 Hz), 10.23 (s, 1H). MS: m/z 502.9 (M++1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582661B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-fa66d20ba079433ba131edc6b98994fb |
| 出典メモ | uspto-grants-2009_09 |