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Dimethyl 5-nitroisophthalate → Dimethyl 5-aminoisophthalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl 5-nitroisophthalate | HCID 83316 | — |
| 反応物 | 4-Mercapto-5-aminoisophthalic acid hydrochloride | HCID 68993396 | — |
| 生成物 | Dimethyl 5-aminoisophthalate | HCID 66831 | — |
反応手順
The AB2 monomer, 4-mercapto-5-aminoisophthalic acid hydrochloride, is synthesized in similar fashion, starting with catalytic hydrogenation of dimethyl 5-nitroisophthalate to form the corresponding amine, dimethyl-5-aminoisophthalate, which is then acetylated to protect the amino group. Dimethyl-5-aminoisophthalate is treated with thiocyanogen bromide (generated in-situ from bromine and ammonium thiocynate), and finally hydrolyzed to provide the desired monomer.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582719B1 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-99526760e68845849d3b49efed3e0f55 |
| 出典メモ | uspto-grants-2009_09 |