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1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → 6-Methyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| 反応物 | 2-chloro-6-methyl-1H-1,3-benzodiazole | HCID 11629655 | — |
| 生成物 | 6-Methyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 11661247 | — |
反応手順
The reaction of 2-chloro-6-methyl-1H-benzoimidazole (0.261 g, 1.57 mmol, Example14b) with 1-(3-trifluoromethylpyridin-2-yl)piperazine (0.54 g, 1.6 mmol, Maybridge) under the conditions of Example 3c afforded the title compound as a white solid. M.p. 216-217° C. MS (ESI, pos. ion) m/z: 362 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07582761B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-be0cf07b4cbf489cb4174631ca7b20aa |
| 出典メモ | uspto-grants-2009_09 |