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2-Amino-3-benzyloxypyridine → 8-Benzyloxy-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-3-benzyloxypyridine | HCID 90334 | — |
| 反応物 | 4-(Bromoacetyl)-5-methyl-3-phenylisoxazole | HCID 2735531 | — |
| 生成物 | 8-Benzyloxy-2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridine | HCID 24738340 | 50% |
反応手順
As described for Example 2, 4-(bromoacetyl)-5-methyl-3-phenylisoxazole (commercially available) (140 mg, 0.5 mmol) was converted, using 2-amino-3-benzyloxypyridine instead of 2-amino-3-methylpyridine, to the title compound (96 mg, 50%) which was obtained as a light yellow solid. MS: m/e=382.3 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07585874B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-62f7fa825a104343a1edb21b492e7b90 |
| 出典メモ | uspto-grants-2009_09 |