関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Beta-Aminoisobutyric Acid | HCID 64956 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | 3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid | HCID 304274 | — |
反応手順
A solution of 41.7 ml of chloroformic acid benzyl ester (9%) in toluene is added to 25 g of 3-amino-2(R,S)-methylpropionic acid in 533 ml of 1N sodium hydroxide at 0° C. The reaction mixture is then stirred for 30 minutes at 0° C. After the addition of 400 ml of diethyl ether, the aqueous phase is removed and 140 ml of 4N hydrochloric acid are added. The crude title compound is obtained from the organic phase by extraction with diethyl ether: Rf (dichloromethane/methanol=8:2)=0.41.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05559111 |
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| 出典データセット | uspto-grants-1996_09 |
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| ORD ID | ord-8b6927670d334d74a0d3467d024aaf6f |
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| 出典メモ | uspto-grants-1996_09 |
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