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Triethylamine → (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Chloroisonicotinic acid | HCID 236985 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | 5-Fluoroindoline | HCID 2774463 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386590 | — |
反応手順
174 mg (1.27 mmol) 5-fluoro-2,3-dihydro-1H-indole were added to 198 mg (1.26 mmol) 2-chloroisonicotinic acid, 351 μL (2.50 mmol) triethylamine and 434 mg (1.35 mmol) TBTU in 3 mL DMF. The reaction mixture was stirred overnight at RT. Purification was carried out by preparative HPLC. The product fractions were combined and evaporated down i. vac.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829006B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-5d720ad4a5af4249b03846e9b4bcd2f1 |
| 出典メモ | uspto-grants-2014_09 |