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Dichloromethane → 2-Methylene-3-quinuclidone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Methylene-3-quinuclidinone dihydrate hydrochloride | HCID 21954275 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Methylene-3-quinuclidone | HCID 322973 | — |
反応手順
Suspend 95.4 g (0.455 mole) 2-methylene-3-quinuclidinone dihydrate hydrochloride in a solution of 255 g (1.85 moles) anhydrous potassium carbonate dissolved in 350 ml H2O. When the suspension clears add 500 ml methylene chloride and mix the 2-phase system overnight using a mechanical stirrer. Separate the layers and dry the methylene chloride layer over potassium carbonate. Remove the solvents in vacuo to obtain the title compound. Repeat the extraction until most of the product is collected.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04599344 |
| 出典データセット | uspto-grants-1986_07 |
| ORD ID | ord-8487bf1433834c318e8cfa3a4af4c32e |
| 出典メモ | uspto-grants-1986_07 |