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Dichloromethane → HCID 86071219、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Bromoacetyl bromide | HCID 61147 | — |
| 反応物 | 6-Nitroveratryl alcohol | HCID 66097 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | HCID 86071219 | HCID 86071219 | 55.1% |
反応手順
Bromoacetylbromide (0.19 ml, 2.2 mmol) was slowly added to the solution of 6-nitroveratrylalcohol (0.43 g, 2 mmol), Et3N (0.56 ml, 4 mmol) and DMAP (24 mg, 0.2 mmol) in CHCl3 (5 ml). After stirring at room temperature for five hours, CH2Cl2 (20 ml) was added and the mixture was washed with HCl (1 M, 2×10 ml), NaHCO3 (sat., 10 ml) and water (10 ml). Organic phase was dried over Na2SO4, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (368 mg, 55%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07393828B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-7be346b8d40a48e3b16b2cdd7e8b52d1 |
| 出典メモ | uspto-grants-2008_07 |