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Acetic Acid → Bromomethyl 3-methoxyphenyl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 6-Acetyltetralin | HCID 69885 | — |
| 生成物 | Bromomethyl 3-methoxyphenyl ketone | HCID 101294 | 28.9% |
反応手順
Reaction of 1-(5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanone (5 g, 28.70 mmol), acetic acid (1.6 mL, 28.70 mmol), and bromine (1.7 mL, 33.00 mmol) followed by recrystallisation from cold EtOAc/Hexane gave the title compound (1.9 g, 26%) as a yellow powder. 1H NMR (300 MHz, CD3OD) δ 1.84 (t, 4H, J=6.6 Hz), 2.80-2.85 (m, 4H), 4.61 (s, 2H), 7.19 (d, 1H, J=8.7 Hz), 7.70-7.78 (m, 2H). ES-MS m/z 253 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07396840B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-5335607b10a84cabb632b284682e8842 |
| 出典メモ | uspto-grants-2008_07 |