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Sodium hydride → 2-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Bromo-1,1,1-trifluoropropane | HCID 2725114 | — |
| 反応物 | 2-(4-Methoxybenzyl)malononitrile | HCID 2764141 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(4-Methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile | HCID 22235014 | 27.7% |
反応手順
Using 0.39 g of 2-(4-methoxybenzyl)malononitrile, 5 ml of N,N-dimethylformamide, 0.12 g of sodium hydride (60% in oil), and 0.34 g of 1-bromo-3,3,3-trifluoropropane, and according to the process described in the Production Example 1, there was obtained 0.15 g of 2-(4-methoxybenzyl)-2-(3,3,3-trifluoropropyl)malononitrile (the present compound (89)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07402691B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-7bc74f264c974fa9b95d4105bebdbf2c |
| 出典メモ | uspto-grants-2008_07 |