化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Iodide → (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-(1H-Indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide | HCID 68825664 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (6-{[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynylcarbamoyl]-methyl}-indol-1-yl)-acetic acid ethyl ester | HCID 68822191 | — |
反応手順
In analogy to the procedure described for example 1 b], 2-(1H-indol-6-yl)-N-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-acetamide was reacted with bromo-acetic acid ethyl ester in the presence of cesium carbonate and potassium iodide in acetonitrile under reflux conditions to give the title compound as off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07405236B2 |
| 出典データセット | uspto-grants-2008_07 |
| ORD ID | ord-64f3c470e8ab46bf901b8c4e2407e75c |
| 出典メモ | uspto-grants-2008_07 |