関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 4-trimethylsilylethynylbenzoate | HCID 640161 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Methyl 4-ethynylbenzoate | HCID 640163 | — |
反応手順
18.1 g (77.9 mmol) 4-trimethylsilanylethynyl-benzoic acid methyl ester are added to 400 mL MeOH, cooled down to 0° C. and charged with 3.24 g (23.4 mmol) K2CO3. The reaction mixture is stirred for 3 h, then the solvent is removed in vacuo and the resulting residue is purified by column chromatography (silica gel, hexane/TBME 10/1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08835472B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-de8bb91a8f924b978552978698209a98 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
