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Tetrahydrofuran → 2-ethyl-4-(perfluorophenylcarbonyl)-8-(prop-1-enyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Pentafluorobenzoyl chloride | HCID 75256 | — |
| 反応物 | Oxazinone | HCID 21873527 | — |
| 生成物 | 2-ethyl-4-(perfluorophenylcarbonyl)-8-(prop-1-enyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | HCID 131731875 | 63% |
反応手順
Procedure & NMR Data: 265 μL of pentafluorobenzoyl chloride (2 eq, 1.84 mmol) was added to a mixture of 148 mg of NaH (4 eq, 3.68 mmol) and 200 mg (0.92 mmol) of oxazinone P2 in THF (22 ml). 240 mg of P5 were obtained, yield 63%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835628B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-0753b1db55304e0794165cca15c7aa25 |
| 出典メモ | uspto-grants-2014_09 |