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Tetrahydrofuran → 4-(2,4-dimethoxyphenylcarbonyl)-2-ethyl-8-(prop-1-enyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 2,4-Dimethoxybenzoyl chloride | HCID 2734719 | — |
| 反応物 | Oxazinone | HCID 21873527 | — |
| 生成物 | 4-(2,4-dimethoxyphenylcarbonyl)-2-ethyl-8-(prop-1-enyl)-2H-benzo[b][1,4]oxazin-3(4H)-one | HCID 68025183 | 84% |
反応手順
Procedure & NMR Data: 162 mg (2.5 eq, 0.8 mmol) of 2,4-Dimethoxybenzoyl chloride was added to a mixture of 49 mg (4 eq, 1.28 mmol) of NaH and 73 mg (0.32 mmol) of oxazinone P2 in THF (14 mL). 109 mg of P9 were obtained, yield 84%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08835628B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7e118ac479cc4682b6453e374ddeddfb |
| 出典メモ | uspto-grants-2014_09 |