関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | m-Aminoacetanilide | HCID 7604 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Ethyl bromophenylacetate | HCID 97780 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | (3-Acetylamino-phenylamino)-phenyl-acetic acid ethyl ester | HCID 59401202 | 86% |
反応手順
N-(3-Aminophenyl)acetamide (371 mg, 2.47 mmol), ethyl 2-bromo-2-phenylacetate (0.29 mL, 1.64 mmol), and DIPEA (0.43 mL, 2.47 mmol) are dissolved in acetonitrile (5 mL). The reaction is heated under MW irradiation at 100° C. for 30 minutes. Conversion complete by UPLC/MS-UV. Acetonitrile is evaporated and the crude residue is purified by flash chromatography (DCM/EtOAc=8/2) to obtain intermediate I92 as a colorless oil (440 mg, 86% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08835682B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-710f35955fd94a4ca0538bffada3a3b1 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
