関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Bromoethyl methyl ether | HCID 80972 | — |
| 反応物 | 2-Amino-5-methylthiazole | HCID 351770 | — |
| 生成物 | 3-(2-Methoxyethyl)-5-methyl-3H-thiazol-2-ylideneamine hydrobromide | HCID 66860199 | 40.4% |
反応手順
A mixture of 5-methyl-thiazol-2-ylamine (1.0 g, 8.8 mmol) and 2-bromoethyl methyl ether (1.0 mL, 11 mmol) were heated at 85° C. for 16 hours. The mixture was cooled to ambient temperature, triturated with ethanol and the solid was collected by filtration to afford 0.90 g (40%) of the title compound. 1H NMR (CDCl3, 300 MHz) δ ppm 2.25 (d, J=1.4 Hz, 3H), 3.36 (s, 3H), 3.72-3.81 (m, 2H), 4.36-4.43 (m, 2H), 6.61 (d, J=1.7 Hz, 1H), 9.54 (s, 1H); MS (DCI/NH3) m/z 173 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08841334B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ab8a3ea2a1984611bdc7f72493eab221 |
|---|
| 出典メモ | uspto-grants-2014_09 |
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