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Acetyl isothiocyanate → N-(2-(3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazine-2-carbonyl)hydrazinecarbonothioyl)ethanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl isothiocyanate | HCID 128851 | — |
| 反応物 | 3-Amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide | HCID 59471632 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | N-(2-(3-amino-6-(4-(isopropylsulfonyl)phenyl)pyrazine-2-carbonyl)hydrazinecarbonothioyl)ethanamide | HCID 59471667 | — |
反応手順
A mixture of 3-amino-6-(4-isopropylsulfonylphenyl)pyrazine-2-carbohydrazide (100 mg, 0.2982 mmol), acetyl isothiocyanate (30.16 mg, 26.20 μL, 0.2982 mmol) and dry DCE (2.000 mL) were stirred at ambient temperature for 2 h and then concentrated in vacuo. Used directly in the next step without further purification; MS (ES+) 437.20
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841308B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-69524c100c5247dc8905c65244ff7dc6 |
| 出典メモ | uspto-grants-2014_09 |