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Dichloromethane → Dichloromethane methanol ammonium hydroxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67259729 | — |
| 反応物 | (3R,4R)-tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)-3-fluoropiperidine-1-carboxylate | HCID 67261845 | — |
| 生成物 | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| 生成物 | N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67259729 | — |
反応手順
Preparation of (N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide: To (3R,4R)-tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)-3-fluoropiperidine-1-carboxylate (12 mg, 0.02 mmol) in DCM (1 mL) was added TFA (1 mL). The reaction was stirred for one hour and concentrated. Silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) provided the desired product (7 mg). MS (ES+APCI) m/z=514 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841455B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-b219d40e09d74712a760c2898f6b3d0d |
| 出典メモ | uspto-grants-2014_09 |