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tert-Butyl piperazine-1-carboxylate → 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | 2-isobutyl-4-methanesulfonyloxy-6-phenyl-2H-pyridazin-3-one | HCID 21991554 | — |
| 反応物 | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one | HCID 67214099 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-2-isobutyl-6-phenyl-2H-pyridazin-3-one | HCID 67213386 | 83.5% |
反応手順
Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxy-6-phenyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted in N,N-dimethylformamide as a solvent to yield the title compound as a yellow oil (yield: 83.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087606B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-3644b3e033524ed4a71bf1b7ba9b6fa0 |
| 出典メモ | uspto-grants-2006_08 |